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General Nephrology

News, opinions and meeting coverage in nephrology.

Morning Break over illustration of a syringe, Covid virus, and DNA helix over a photo of green vegetation.

Ex-Gov. May Face Charges Over COVID; Autism Dx Up 175%; Can Fasting Help Kidneys?

Health news and commentary gathered by 木瓜直播 staff

FDA ADCOMM sotagliflozin over a computer rendering of chronic kidney disease.

FDA Staff Not Quite Sold on Sotagliflozin for T1D Patients With CKD

SGLT1/SGLT2 inhibitor has another shot in T1D, but now in more narrow patient population

A selfie of Brittany Randall and her daughter Kamberlyn Bowler in Grand Junction Colorado in the summer of 2024.

Colorado Teen Fights Kidney Failure After Eating McDonald's Quarter Pounders

Deadly E. coli outbreak has been tentatively traced to contaminated onions

ASN over a photo of San Diego Convention Center in San Diego, CA.

Wegovy Cut Albuminuria by Half in Non-Diabetic CKD

However, 24 weeks of the GLP-1 had no impact on eGFR

ASN over a photo of San Diego Convention Center in San Diego, CA.

Early AKI Care Recommendations Did Not Improve Patient Outcomes

Personalized recs were made by team of physicians and pharmacists within an hour of diagnosis

ASN over a photo of San Diego Convention Center in San Diego, CA.

SGLT2 Inhibitor Carry-Over Benefits Last How Long?

Trial follow-up defines the need for long-term treatment in protecting the kidneys and heart

ASN over a photo of San Diego Convention Center in San Diego, CA.

Kidney Disease Genetic Risk Common in West Africans

Observational study points to genetic risk allele dose-response

ASN over a photo of San Diego Convention Center in San Diego, CA.

No Kidney Benefit With Finerenone in Heart Failure Patients

Anti-mineralocorticoid agent reduced albuminuria, but not eGFR-based kidney outcome

ASN over a photo of San Diego Convention Center in San Diego, CA.

Complement Inhibitor Shows Promise for Rare Kidney Disorder

Ravulizumab reduced proteinuria, stabilized eGFR in IgA nephropathy

ASN over a photo of San Diego Convention Center in San Diego, CA.

Interim ALIGN Data: Atrasentan Cuts Proteinuria in IgA Nephropathy

Surrogate endpoint of urinary protein-to-creatinine ratio "widely considered to be predictive"

ASN over a photo of San Diego Convention Center in San Diego, CA.

Alternative Pathway Inhibition Makes Good in IgA Nephropathy

Treatment with iptacopan reduces proteinuria in interim APPLAUSE-IgAN analysis

ASN over a photo of San Diego Convention Center in San Diego, CA.

Pediatric Febrile UTI May Hurt Kidney Function

Study also raises question of antibiotic prophylaxis in kids with common congenital anomaly

ASN over a photo of San Diego Convention Center in San Diego, CA.

木瓜直播 Transplant Trouble Spelled Out for Newer Rejection Episode Categories

Study details an intermediate prognosis with newer microvascular inflammation phenotypes

A close-up of a filter attached to an extracorporeal blood purification machine.

Cardiac Surgery-Associated AKI Lower With Extracorporeal Blood Purification

Device yields 10% absolute reduction in acute kidney injury within a week of surgery

A photo of free weights in a gym.

Can Exercise Bring on Rhabdomyolysis?

A sports cardiologist explains the condition that hospitalized nine Tufts lacrosse players

A computer rendering of the thyroid with the parathyroid glands highlighted.

Early Parathyroidectomy No Boon for Preventing Depression

But neurocognitive effects of surgery may be more subtle than a clinical depression diagnosis

Amino Acids May Protect Kidneys During Surgery; EDTA for Chelation Therapy

Also in TTHealthWatch: suicidality among spouses of people with cancer

A computer rendering of a transparent human body with the kidneys highlighted.

Renal Impairment Tracks With Rheumatoid Arthritis Disease Activity

Study highlights another reason to keep RA under control

Medicare Unveils First 10 Negotiated Drug Prices

Prices slashed by as much as 79%

FDA APPROVED iptacopan (Fabhalta) over a computer rendering of a transparent body with a kidney highlighted.

FDA OKs Complement Inhibitor for IgA Nephropathy

First-in-class iptacopan approved to reduce proteinuria in adults with rare progressive disease

A computer rendering of a transparent body with the kidneys highlighted.

This Drug Class Keeps AA Amyloidosis in Check

Staves off end-stage renal disease, retrospective study indicates

Do People Buy Into Hospital-at-Home Care?; Nicotine Pouch Use

Also in TTHealthWatch: preventing kidney transplant rejection

A close up photo of a senior woman鈥檚 hand with an intravenous line attached.

Diuretics for Ambulatory HF Patients With Volume Overload: Winners & Losers

Three regimens compared head-to-head among abundant choices

A photo of a woman preparing her husband for home dialysis.

Medicare's Financial Incentives Still Falling Flat for Home Dialysis Uptake

Kidney transplants did not increase either

A photo of a prescription bottle of metformin tablets next to a glucose monitor.

Lupus Complications Reduced With Common Diabetes Drug

Metformin benefits seen extending way beyond its glucose-lowering properties

A photo of surgeons and a cardiopulmonary bypass machine in the operating room.

Amino Acid Infusion Before Cardiac Surgery Reduced Acute Kidney Injury

The amino acid mixture reduced stage 3 AKI by 44% compared with placebo

EULAR over a photo of Vienna Exhibition Center in Vienna, Austria.

CAR-T Treatment Continues to Astonish in Rheumatologic Diseases

Numbers of patients, length of follow-up keep growing with no visible downside (yet)

Hypertension After Kidney Donation; Statins in Old and Very Old People

Also in TTHealthWatch: fluoride's effect on pregnancy outcomes

A computer rendering of antibodies in the blood.

Monoclonal Antibody May Benefit Patients With 木瓜直播 Transplant Rejection

But results were not fully durable after treatment cessation

A close up photo of Ozempic injection pens.

Ozempic Protects Kidneys, Boosts Survival in Diabetes Patients With CKD

Phase III trial adds a fourth class shown to benefit this population

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

PROTECT Drugs Tied to Slower eGFR Decline vs Standard Care in IgA Nephropathy

Slower kidney function decline observed with sparsentan and irbesartan

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Many Patients With CKD Never Receive a Diagnosis

These are people who are getting tested and seeing doctors, but still not getting diagnosed

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Gastrointestinal Bleeding More Common in Advanced CKD

Risk was significantly higher regardless of dialysis status

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Not All Nephrologists Measure Kidney Size in 'Adult' Polycystic Kidney Disease

Of those who do, 88% reported using the gold-standard imaging biomarker in determining prognosis

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Sparsentan Bests Irbesartan for Rare, Progressive Kidney Disease

However, the FDA remains unconvinced that results support a new indication for the drug

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Blood Disorder Drug Cuts Proteinuria in Rare Kidney Disorder

Reduced 24-hour UPCR by 38.3%

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Draw Between Two Diuretics for Renal Prevention in Hypertension

But researcher questions if patients were underdosed

A computer rendering of chronic kidney disease.

Industry Clinic 鈥� Ad Insights

Recognizing Racial Disparities Impacting Rare Kidney Disease Patients

A photo of a female nurse preparing her senior male patient for dialysis.

QT-Prolonging Meds Commonly Doled Out to Dialysis Patients

Most scripts originated from clinicians other than nephrologists

Paxlovid and COVID; Breast Cancer and Lymph Node Removal

Also in TTHealthWatch: pragmatic model for chronic kidney disease

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