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General Nephrology

News, opinions and meeting coverage in nephrology.

ASN over a photo of San Diego Convention Center in San Diego, CA.

Interim ALIGN Data: Atrasentan Cuts Proteinuria in IgA Nephropathy

Surrogate endpoint of urinary protein-to-creatinine ratio "widely considered to be predictive"

ASN over a photo of San Diego Convention Center in San Diego, CA.

Alternative Pathway Inhibition Makes Good in IgA Nephropathy

Treatment with iptacopan reduces proteinuria in interim APPLAUSE-IgAN analysis

ASN over a photo of San Diego Convention Center in San Diego, CA.

Pediatric Febrile UTI May Hurt Kidney Function

Study also raises question of antibiotic prophylaxis in kids with common congenital anomaly

ASN over a photo of San Diego Convention Center in San Diego, CA.

木瓜直播 Transplant Trouble Spelled Out for Newer Rejection Episode Categories

Study details an intermediate prognosis with newer microvascular inflammation phenotypes

A close-up of a filter attached to an extracorporeal blood purification machine.

Cardiac Surgery-Associated AKI Lower With Extracorporeal Blood Purification

Device yields 10% absolute reduction in acute kidney injury within a week of surgery

A photo of free weights in a gym.

Can Exercise Bring on Rhabdomyolysis?

A sports cardiologist explains the condition that hospitalized nine Tufts lacrosse players

A computer rendering of the thyroid with the parathyroid glands highlighted.

Early Parathyroidectomy No Boon for Preventing Depression

But neurocognitive effects of surgery may be more subtle than a clinical depression diagnosis

Amino Acids May Protect Kidneys During Surgery; EDTA for Chelation Therapy

Also in TTHealthWatch: suicidality among spouses of people with cancer

A computer rendering of a transparent human body with the kidneys highlighted.

Renal Impairment Tracks With Rheumatoid Arthritis Disease Activity

Study highlights another reason to keep RA under control

Medicare Unveils First 10 Negotiated Drug Prices

Prices slashed by as much as 79%

FDA APPROVED iptacopan (Fabhalta) over a computer rendering of a transparent body with a kidney highlighted.

FDA OKs Complement Inhibitor for IgA Nephropathy

First-in-class iptacopan approved to reduce proteinuria in adults with rare progressive disease

A computer rendering of a transparent body with the kidneys highlighted.

This Drug Class Keeps AA Amyloidosis in Check

Staves off end-stage renal disease, retrospective study indicates

Do People Buy Into Hospital-at-Home Care?; Nicotine Pouch Use

Also in TTHealthWatch: preventing kidney transplant rejection

A close up photo of a senior woman鈥檚 hand with an intravenous line attached.

Diuretics for Ambulatory HF Patients With Volume Overload: Winners & Losers

Three regimens compared head-to-head among abundant choices

A photo of a woman preparing her husband for home dialysis.

Medicare's Financial Incentives Still Falling Flat for Home Dialysis Uptake

Kidney transplants did not increase either

A photo of a prescription bottle of metformin tablets next to a glucose monitor.

Lupus Complications Reduced With Common Diabetes Drug

Metformin benefits seen extending way beyond its glucose-lowering properties

A photo of surgeons and a cardiopulmonary bypass machine in the operating room.

Amino Acid Infusion Before Cardiac Surgery Reduced Acute Kidney Injury

The amino acid mixture reduced stage 3 AKI by 44% compared with placebo

EULAR over a photo of Vienna Exhibition Center in Vienna, Austria.

CAR-T Treatment Continues to Astonish in Rheumatologic Diseases

Numbers of patients, length of follow-up keep growing with no visible downside (yet)

Hypertension After Kidney Donation; Statins in Old and Very Old People

Also in TTHealthWatch: fluoride's effect on pregnancy outcomes

A computer rendering of antibodies in the blood.

Monoclonal Antibody May Benefit Patients With 木瓜直播 Transplant Rejection

But results were not fully durable after treatment cessation

A close up photo of Ozempic injection pens.

Ozempic Protects Kidneys, Boosts Survival in Diabetes Patients With CKD

Phase III trial adds a fourth class shown to benefit this population

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

PROTECT Drugs Tied to Slower eGFR Decline vs Standard Care in IgA Nephropathy

Slower kidney function decline observed with sparsentan and irbesartan

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Many Patients With CKD Never Receive a Diagnosis

These are people who are getting tested and seeing doctors, but still not getting diagnosed

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Gastrointestinal Bleeding More Common in Advanced CKD

Risk was significantly higher regardless of dialysis status

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Not All Nephrologists Measure Kidney Size in 'Adult' Polycystic Kidney Disease

Of those who do, 88% reported using the gold-standard imaging biomarker in determining prognosis

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Sparsentan Bests Irbesartan for Rare, Progressive Kidney Disease

However, the FDA remains unconvinced that results support a new indication for the drug

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Blood Disorder Drug Cuts Proteinuria in Rare Kidney Disorder

Reduced 24-hour UPCR by 38.3%

NKF over a photo of Long Beach Convention and Entertainment Center, in Long Beach, CA

Draw Between Two Diuretics for Renal Prevention in Hypertension

But researcher questions if patients were underdosed

A computer rendering of chronic kidney disease.

Industry Clinic 鈥� Ad Insights

Recognizing Racial Disparities Impacting Rare Kidney Disease Patients

A photo of a female nurse preparing her senior male patient for dialysis.

QT-Prolonging Meds Commonly Doled Out to Dialysis Patients

Most scripts originated from clinicians other than nephrologists

Paxlovid and COVID; Breast Cancer and Lymph Node Removal

Also in TTHealthWatch: pragmatic model for chronic kidney disease

A photo of the San Francisco skyline.

California Sets Long-Awaited Drinking Water Limit for 'Erin Brockovich' Contaminant

The rule is the first in the nation to specifically target the heavy metal

A photo of two bottles of risperidone tablets.

Antipsychotics in Dementia Tied to Wider Range of 'Serious Harms'

Steepest increases in risk observed for pneumonia, kidney injury, VTE, and stroke

A computer rendering of a transparent body with the kidneys highlighted.

TNF Inhibitors for IBD Linked to Kidney Function Declines

Observational VA data support recommendations for monitoring with initiation

A photo of a woman receiving dialysis in a clinic.

Multidisciplinary Team Intervention Flops for Improving CKD Outcomes

Intervention "did not overcome barriers" to PCP, patient behavior changes, editorialists say

A photo of a surgeon performing an intravitreal injection.

No Difference in Kidney Failure Risk Between Three Anti-VEGF Agents for Eye Disease

"We can let other factors guide our treatment," researcher says

A photo of a mature man receiving dialysis in a hospital.

Primary Care Strategy Fails to Reduce Kidney-Dysfunction Triad Hospitalizations

Secondary outcomes also showed no significant differences

FDA APPROVED vadadustat (Vafseo) over a photo of a woman receiving dialysis.

Once-Rejected Drug Now FDA Approved for CKD-Related Anemia

Indication for HIF-PH inhibitor vadadustat limited to patients already on dialysis

A photo of surgeons performing the pig kidney transplant.

First-Ever Pig 木瓜直播 Transplant Performed in Living Recipient

Patient with end-stage kidney disease underwent transplant at Massachusetts General Hospital

A photo of a stylist applying hair-straightening cream to her female client.

Acute Kidney Injury: The Price of Straight Hair?

Case study highlights dangers of glyoxylic acid-containing products

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